Research at the University of Michigan Frankel Cardiovascular Center

The University of Michigan Frankel Cardiovascular Center (CVC) is at the forefront of cardiovascular research thanks to the engagement of our faculty, a culture of collaboration and innovation, and support for both clinical research and basic science. This long-standing focus on research has been part of our history since the University of Michigan established its medical school in 1848. (Visit our digital timeline to view the contributions of U-M cardiovascular researchers over the past 100-plus years.)

The Frankel Cardiovascular Center’s commitment to research is an important differentiator that allows researchers to contribute to the global body of cardiovascular research and ensures patients have access to the latest cardiovascular clinical trials and therapies. 

Clinical Trials: Advancing the Prevention and Treatment of Cardiovascular Disease

Clinical research isn't possible without the help of volunteers, both healthy and affected by specific illnesses and conditions. Hundreds of people take part in cardiovascular clinical trials each year, and our researchers are always seeking more volunteers. Key clinical research areas include: 

  • Arrhythmia
  • Heart Failure & LVAD
  • Stroke
  • Heart Valve Disease
  • Thrombosis and DVT

Become a Cardiovascular Research Volunteer

Visit the Cardiovascular Research Studies page to learn more about how to become a cardiovascular research study participant.

Resources for Researchers

The Frankel Cardiovascular Center offers an array of services for researchers, both within the University of Michigan research community and throughout the world:

  • Physiology and Phenotyping Core: Provides state of the art phenotyping services for animal models ranging from zebrafish all the way to large animals, with a primary focus on mouse and rodent models of disease. Services include: Cardiac Pressure /Volume Analysis; Echocardiography; Exercise and Neuromuscular Testing; Microsurgical Models; Non-Invasive Blood Pressure; Telemetry; and Ultrasound. Visit the U-M Physiology and Phenotyping Core Laboratory website for more information.
  • Cardiovascular Regeneration Core: Generates patient-specific induced pluripotent stem cells (hiPSCs) for basic science research purposes. Operates on a fee-for-service basis to serve the research community in its needs to derive patient specific iPSCs and differentiated cardiovascular cell types. Services include: Fibroblast Expansion; Reprogramming to iPSCs; Maintenance and Characterization of iPSCs; hiPSC-CM purification; and Differentiation to Vascular Cells. Visit the U-M Cardiovascular Regeneration Core Laboratory website for more information. 
  • Heart Vessel Blood Clinical Trial Support Unit: Clinical Trial Support Units (CTUs) are are business units that partner with investigators and their teams to ensure the timely and efficient activation and execution of Michigan Medicine clinical trials. The Heart Vessel Blood (HVB) CTU works to enhance performance of cardiovascular, coagulation, and nonmalignant hematologic across the lifespan of acute and chronic disease. Offers specialty recruitment services, quality assurance and junior faculty support. Visit the Heart Vessel Blood CTU page on the Clinical Trials Support Office website for more information.