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Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, Evangelista A, Fattori R, Suzuki T, Oh JK, Moore AG, Malouf JF, Pape LA, Gaca C, Sechtem U, Lenferink S, Deutsch HJ, Diedrichs H, Robles JM, Llovet A, Gilon D, Das SK, Armstrong WF, Deeb GM, Eagle KA. The International Registry of Aortic Dissection (IRAD): New insights into an old disease. JAMA 2000; 283(7):897-903.
Mehta RH, Suzuki T, Hagan PG, Bossone E, Gilon D, Llovet A, Maroto LC, Cooper JV, Smith DE, Armstrong WF, Nienaber CA, Eagle KA. Predicting death in patients with acute type A aortic dissection. Circulation 2002; 105(2):200-206.
Januzzi JL, Sabatine MS, Eagle KA, Evangelista A, Bruckman D, Fattori R, Oh JK, Moore AG, Sechtem U, Llovet A, Gilon D, Pape L, O’Gara PT, Mehta R, Cooper JV, Hagan PG, Armstrong WF, Deeb GM, Suzuki T, Nienaber CA, Isselbacher EM. Iatrogenic aortic dissection. Am J of Cardiology 2002; 89(5):623-626.
Moore AG, Eagle KA, Bruckman D, Moon BS, Malouf JF, Fattori R, Evangelista A, Isselbacher EM, Suzuki T, Nienaber CA, Gilon D, Oh JK. Choice of computed tomography, transesophageal echocardiography, magnetic resonance imaging, and aortography in acute aortic dissection: International Registry of Acute Aortic Dissection (IRAD). Am J of Cardiology 2002; 89:1235-1238.
Bossone E, Rampoldi V, Nienaber CA, Trimarchi S, Ballotta A, Cooper JV, Smith DE, Eagle KA, Mehta RH. Usefulness of pulse deficit to predict in-hospital complications and mortality in patients with acute type A aortic dissection. Am J of Cardiology 2002; 89:851-855.
Nallamothu BK, Mehta RH, Saint S, Llovet A, Bossone E, Cooper JV, Sechtem U, Isselbacher EM, Nienaber CA, Eagle KA, Evangelista A. Syncope in acute aortic dissection: diagnostic, prognostic, and clinical implications. Am J of Medicine 2002; 113:468-471.
Mehta RH, O’Gara PT, Bossone E, Nienaber CA, Myrmel T, Cooper JV, Smith DE, Armstrong WF, Isselbacher EM, Pape LA, Eagle KA, Gilon D. Acute type A aortic dissection in the elderly: clinical characteristics, management and outcomes in the current era. J Am Coll Cardiol 2002; 40:685-692.
Mehta RH, Manfredini R, Hassan F, Sechtem U, Bossone E, Oh JK, Cooper JV, Smith DE, Portaluppi F, Penn M, Hutchison S, Nienaber CA, Isselbacher EM, Eagle KA. Chronobiological patterns of acute aortic dissection. Circulation 2002; 106:1110-1115.
Eagle KA, Isselbacher EM, DeSanctis RW. Cocaine-related aortic dissection in perspective. Circulation 2002; 105:1529-1530.
Nienaber CA, Eagle KA. Aortic dissection: new frontiers in diagnosis and management. Part I: from etiology to diagnostic strategies. Circulation 2003; 108:628-635.
Nienaber CA, Eagle KA. Aortic dissection: new frontiers in diagnosis and management. Part II: therapeutic management and follow-up. Circulation 2003; 108:772-778.
Suzuki T, Mehta RH, Ince H, Nagai R, Sakomura Y, Weber F, Sumiyoshi T, Bossone E, Trimarchi S, Cooper JV, Smith DE, Isselbacher EM, Eagle KA, Nienaber CA. Clinical profiles and outcomes of acute type B aortic dissection– lessons from the International Registry of Aortic Dissection (IRAD). Circulation 2003; 108[suppl II]:312-317.
Januzzi JL, Isselbacher EM, Fattori R, Cooper JV, Smith DE, Fang J, Eagle KA, Mehta RH, Nienaber CA, Pape LA. Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 2004; 43:665-669.
Mehta RH, Bossone E, Evangelista A, O’Gara PT, Smith DE, Cooper JV, Oh JK, Januzzi JL, Hutchison S, Gilon D, Pape LA, Nienaber CA, Isselbacher EM, Eagle KA. Acute type B aortic dissection in elderly patients: clinical features, outcomes and simple risk stratification rule. Ann Thorac Surg 2004; 77:1622-29.
Nienaber CA, Fattori R, Mehta RH, Richartz BM, Evangelista A, Petzch M, Cooper JV, Januzzi JL, Ince H, Sechtem U, Bossone E, Fang J, Smith DE, Isselbacher EM, Pape LA, Eagle KA . Gender-related differences in acute aortic dissection. Circulation 2004; 109:3014-3019.
Januzzi JL, Al-Marayati F, Mehta RH, Cooper JV, O'Gara PT, Sechtem U, Bossone E, Evangelista A, Oh JK, Nienaber CA, Eagle KA, Isselbacher EM. Comparison of aortic dissection in patients with and without marfan’s syndrome (results from the International Registry of Aortic Dissection). Am J of Cardiol 2004; 94:400-402.
Park SW, Hutchison S, Mehta, RH, Isselbacher EM, Cooper JV, Fang J, Evangelista A, Llovet A, Nienaber CA, Suzuki T, Pape LA, Eagle KA, Oh JK. Association of painless acute aortic dissection with increased mortality. Mayo Clin Proc 2004; 79:1252-1257.
Collins JS, Evangelista A, Nienaber CA, Bossone E, Fang J, Cooper JV, Smith DE, O'Gara PT, Myrmel T, Gilon D, Isselbacher EM, Penn M, Pape LA, Eagle KA, Mehta RH. Differences in clinical presentation, management and outcomes of acute type A aortic dissection in patients with and without prior cardiac surgery. Circulation 2004; 110[suppl II]:237-242.
Beckman JA, Mehta RH, Isselbacher EM, Bossone E, Cooper JV, Smith DE, Fang J, Sechtem U, Pape LA, Myrmel T, Nienaber CA, Eagle KA, O’Gara PT. Mortality and branch vessel complications are increased in aortic dissection patients with renal failure. Vasc Med 2004; 9(4):267-270.
Trimarchi S, Nienaber CA, Rampoldi V, Myrmel T, Suzuki T, Mehta RH, Bossone E, Cooper JV, Smith DE, Menicanti L, Frigiola A, Oh JK, Deeb GM, Isselbacher EM, Eagle KA. Contemporary results of surgery in acute type A aortic dissection: the International Registry of Acute Aortic Dissection experience. J Thorac Cardiovasc Surg 2005; 129:112-122.
Tsai TT, Bossone E, Isselbacher EM, Nienaber CA, Evangelista A, Fang J, Smith DE, Cooper JV, Hutchison S, O’Gara P, Eagle KA, Mehta RH. Clinical characteristics of hypotension in patients with acute aortic dissection. Am J Cardiol 2005; 95:48-52.
Evangelista A, Mukherjee D, Mehta RH, O’Gara PT, Fattori R, Cooper JV, Smith DE, Oh JK, Hutchison S, Sechtem U, Isselbacher EM, Nienaber CA, Pape LA, Eagle KA. Acute intramural hematoma of the aorta: a mystery in evolution. Circulation 2005; 111:1063-1070.
Upchurch GR, Nienaber CA, Fattori R, Evangelista A, Oh JK, MD, Cooper JV, Isselbacher EM, Suzuki T, Eagle KA. Acute aortic dissection presenting with primarily abdominal pain: a rare manifestation of a deadly disease. Ann Vasc Surg 2005; 19:367-373.
Mehta RH, Manfredini R, Bossone E, Hutchison S, Evangelista A, Boari B, Cooper JV, Smith DE, O’Gara PT, Gilon D, Pape LA, Nienaber CA, Isselbacher EM, Eagle KA. Does circadian and seasonal variation in occurrence of acute aortic dissection influence in-hospital outcomes? Chronobiology International 2005; 22:343-351.
Januzzi JL, Eagle KA, Cooper JV, Fang J, Sechtem U, Myrmel T, Evangelista A, Oh JK, Llovet A, O’Gara PT, Nienaber CA, Isselbacher EM. Acute aortic dissection presenting with congestive heart failure: results from the International Registry of Acute Aortic Dissection. J Am Coll Cardiol 2005; 46:733-735.
Mukherjee D, Evangelista A, Nienaber CA, Sechtem U, Suzuki T, Trimarchi S, Llovet A, Myrmel T, O’Gara PT, Fang J, Cooper JV, Oh JK, Januzzi, JL, Hutchison S, Fattori R, Pape LA, Isselbacher EM, Eagle KA. Implications of periaortic hematoma in patients with acute aortic dissection: (from the International Registry of Acute Aortic Dissection). Am J Cardiol 2005; 96:1734-1738.
Tsai TT, Nienaber CA, Eagle KA. Contemporary reviews in cardiovascular medicine: acute aortic syndromes. Circulation 2005; 112:3802-3813.
Trimarchi S, Nienaber CA, Rampoldi V, Myrmel T, Suzuki T, Bossone E, Tolva V, Deeb MG, Upchurch GR, Cooper JV, Fang J, Isselbacher EM, Sundt T, Eagle KA. Role and results of surgery in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114:357-364.
Henke PK, Williams DM, Upchurch GR, Proctor M, Cooper JV, Fang J, Nienaber CA, Isselbacher EM, Fattori R, Dasika N, Gemmete J, Stanley JC, Wakefield TW, Eagle KA. Acute limb ischemia associated with type B aortic dissection: clinical relevance and therapy. Surgery 2006; 140:532-539.
Tsai TT, Evangelista A, Nienaber CA, Trimarchi S, Sechtem U, Fattori R, Myrmel T, Pape L, Cooper JV, Smith DE, Fang J, Isselbacher E, Eagle KA. Long-term survival in patients presenting with type A acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114[suppl I]:350-356.
Tsai TT, Fattori R, Trimarchi S, Isselbacher E, Myrmel T, Evangelista A, Hutchison S, Sechtem U, Cooper JV, Smith DE, Pape L, Froehlich J, Raghupathy A, Januzzi JL, Eagle KA, Nienaber CA. Long-term survival in patients presenting with type B acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114:2226-2231.
Rampoldi V, Trimarchi S, Eagle KA, Nienaber CA, Oh JK, Bossone E, Myrmel T, Sangiorgi GM, De Vincentiis C, Cooper JV, Fang J, Smith D, Tsai T, Raghupathy A, Fattori R, Sechtem U, Sundt TM, Isselbacher EM. Simple risk models to predict surgical mortality in acute aortic dissection: the International Registry of Acute Aortic Dissection score. Ann Thorac Surg 2007; 83:55-61.
Tsai TT, Isselbacher EM, Trimarchi S, Bossone E, Pape L, Januzzi JL, Evangelista A, Oh JK, Llovet A, Beckman J, Cooper JV, Smith DE, Froehlich JB, Fattori R, Eagle KA, Nienaber CA. Acute type B aortic dissection: does aortic arch involvement affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2007; 116[suppl I]:150-156.
Bossone E, Evangelista A, Isselbacher E, Trimarchi S, Hutchison S, Gilon D, Llovet A, O’Gara P, Cooper JV, Fang J, Januzzi JL, Mehta RH, Distante A, Nienaber CA, Eagle KA, Armstrong WF. Prognostic role of transesophageal echocardiography in acute type A aortic dissection. Am Heart J 2007; 153:1013-1020.
Tsai TT, Evangelista A, Nienaber CA, Myrmel T, Meinhardt G, Cooper JV, Smith DE, Suzuki T, Fattori R, Llovet A, Froehlich J, Hutchison S, Distante A, Sundt T, Beckman J, Januzzi J, Isselbacher EM, Eagle KA. Partial thrombosis of the false lumen in patients with acute type B aortic dissection. N Engl J Med 2007; 357:349-359.
Pape LA, Tsai TT, Isselbacher EM, Oh JK, O’Gara PT, Evangelista A, Fattori R, Meinhardt G, Trimarchi S, Bossone E, Suzuki T, Cooper JV, Froehlich JB, Nienaber CA, Eagle KA. Aortic diameter ≥5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2007; 116:1120-1127.
Trimarchi S, Tsai T, Eagle KA, Isselbacher EM, Froehlich J, Cooper JV, Rampoldi V, Upchurch GR. Acute abdominal aortic dissection: insight from the International Registry of Acute Aortic Dissection (IRAD). J Vasc Surg 2007; 46:913-919.
Fattori R, Tsai TT, Myrmel T, Evangelista A, Cooper JV, Trimarchi S, Li J, Lovato L, Kische S, Eagle KA, Li J, Isselbacher EM, Nienaber CA. Complicated acute type B dissection: is surgery still the best option?: a report from the International Registry of Acute Aortic Dissection. J Am Coll Cardiol Intv 2008; 1:395-402.
Raghupathy A, Nienaber CA, Harris KM, Myrmel T, Fattori R, Sechtem U, Oh JK, Trimarchi S, Cooper JV, Booher A, Eagle KA, Isselbacher EM, Bossone E. Geographic differences in clinical presentation, treatment, and outcomes in type A acute aortic dissection (from the International Registry of Acute Aortic Dissection. Am J Cardiol 2008; 102:1562-1566.
Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Uriarte JAS, Schinosa LLT, Renzulli A, Sabino F, Nowak R, Birkhahn R, Hollander JE, Counselman F, Bossone E, Eagle K. Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection. European Heart Journal 2008.
Tsai TT, Trimarchi S, Nienaber CA. Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD). Eur J V Endovasc Surg 2009; 37:149-159.
Gilon D, Mehta RH, Oh JK, Januzzi JL, Bossone E, Cooper JV, Smith DE, Fang J, Nienaber CA, Eagle KA, Isselbacher EM. Characteristics and in-hospital outcomes of patients with cardiac tamponade complicating type A acute aortic dissection. Am J Cardiol 2009; 103(7):1029-31.
Manuscripts In Preparation
Froehlich J, Ramanath VS, Nienaber CA, Smith DE, Cooper JV, Isselbacher EM, Eagle KA. New classification of aortic dissection with improved impact on prognosis – the IRAD classification.
Tsai TT, Nienaber CA, Isselbacher EM, Trimarchi S, Bossone E, Evangelista A, O’Gara PT, Suzuki T, Hutchison S, Cooper JV, Smith DE, Meinhardt G, Myrmel T, Eagle KA, Froehlich JB. Acute type A aortic dissection: does a primary tear in the aortic arch affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD).
Trimarchi S, Nienaber CA, Eagle KA, Rampoldi V, Tsai T, Froehlich J, Evangelista A, Cooper JV, Li J, Meinhardt G, Sundt III T, Bossone E, Isselbacher EM. Role of age in acute type A aortic dissection outcome: Report from The International Registry of Acute Aortic Dissection (IRAD).
Genther D, Isselbacher E, Grzybowski M, Cooper JV, Eagle K, Tsai T, Bossone E, Harris KM, Evangelista A, Fattori R, Ramanath V, Nienaber CA, Froehlich J. Gender and race predict aortic size among type A aortic dissection patients: observations from the International Registry of Acute Aortic Dissection (IRAD).
Shiran H, Nienaber C, Isselbacher E, Tsai T, Meinhardt G, Cooper JV, Grzybowski M, Pyeritz R, Braverman A, Suzuki T, Eagle K, Froehlich JB. Effect of low suspicion presentation of type A acute aortic dissection on care and outcomes: data from the International Registry of Acute Aortic Dissection (IRAD).
Shiran H, Isselbacher E, Nienaber C, Eagle K, Tsai T, Fattori R, Beckman J, O’Gara P, Pape L, Cooper JV, Grzybowski M, Ehrlich M, Froehlich J. Low suspicion presentation of type B acute aortic dissection leads to increased mortality: data from the International Registry of Acute Aortic Dissection (IRAD).
Harris KM, Hirsch AT, Isselbacher EM, Tsai T, Froehlich J, Cooper JV, Fattori R, Strauss C, Evangelista A, Eagle K, Llovet A, Nienaber CA. Gender, clinical, and diagnostic contributors to delayed recognition and treatment of acute aortic dissection: the International Registry of Acute Aortic Dissection (IRAD).
Ramanath VS, Eagle KA, Nienaber CA, Isselbacher EI, Froehlich JB, Cooper JV, Gu X, Evangelista A, Meinhardt G, Beckman J, Myrmel T, Pape LA, Pyeritz RE, Hirsch AT, Bossone E. Role of preoperative coronary angiography in the setting of type A acute aortic dissection: the IRAD experience.
Suzuki T, Isselbacher E, Nienaber CA, Tsai TT, Fattori R, Evangelista A, Braverman AC, Eagle KA, Cooper JV, Ramanath VS, Sechtem U, Hutchison S, Froehlich J. Current medical management at discharge and effect on outcome in type A and B aortic dissection: from the International Registry of Acute Aortic Dissection (IRAD).
Tsai TT, Cooper JV, Woznicki EM, Nienaber CA, Isselbacher CA, Trimarchi S, Booher AM, Evangelista A, Bossone E, Meinhardt G, Fattori R, Pyeritz RE, Eagle KA, Froehlich JB. Trends in management and outcomes of acute aortic dissection: lessons learned from the first 2242 patients enrolled in the International Registry of Acute Aortic Dissection (IRAD).
Isselbacher E, Nienaber CA, Trimarchi S, Evangelista A, Cooper JV, Froehlich JB, Erlich M, Oh J, Januzzi JL, O'Gara P, Sundt T, Harris KM, Bossone E, Pyeritz RE, Eagle KA. The IRAD classification system- a modern method for characterizing mortality risk of aortic dissection based on time from symptom onset, dissection location, and treatment rendered
Trimarchi S, Hutchison S, Isselbacher E, Pape L, Cooper JV, Froehlich JB, Evangelista A, Meinhardt G, Beckman J, Myrmel T, Eagle KA, Pyeritz RE, Hirsch AT, Nienaber CA. Descending aortic diameter of ≥ 6.0 is a poor predictor of type B aortic dissection.
Major Initiatives:
ACS - Global Registry of Acute Coronary Events (GRACE)
IRAD - International Registry of Acute Aortic Dissection
IRAD Sites
IRAD Investigators
IRAD Manuscripts
IRAD Abstracts
