dasatinib

Pronunciation: da SAT in ib

Brand: Sprycel

Sprycel

slide 1 of 7, Sprycel,

70 mg, round, white, imprinted with BMS, 524

Image of Sprycel
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Sprycel

slide 2 of 7, Sprycel,

20 mg, round, white, imprinted with BMS, 527

Image of Sprycel
slide 2 of 7

Sprycel

slide 3 of 7, Sprycel,

50 mg, oval, white, imprinted with BMS, 528

Image of Sprycel
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Sprycel

slide 4 of 7, Sprycel,

100 mg, oval, white, imprinted with BMS 100, 852

Image of Sprycel
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Sprycel

slide 5 of 7, Sprycel,

140 mg, round, white, imprinted with BMS 140, 857

Image of Sprycel
slide 5 of 7

Sprycel

slide 6 of 7, Sprycel,

70 mg, round, white, imprinted with BMS, 524

Image of Sprycel
slide 6 of 7

Sprycel

slide 7 of 7, Sprycel,

80 mg, triangular, white, imprinted with BMS 80, 855

Image of Sprycel
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What is the most important information I should know about dasatinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is dasatinib?

Dasatinib is used in adults and children to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia (CML).

Dasatinib is also used to treat Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) in adults.

Dasatinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dasatinib?

Some people using dasatinib have developed a rare but serious condition called pulmonary arterial hypertension (PAH). PAH occurs when blood pressure increases inside the arteries in your lungs. This makes it harder for your heart to pump blood through the lungs, which also weakens muscles in the heart. PAH may be irreversible if not promptly treated, and this condition can be fatal. Talk to your doctor about your specific risk of developing PAH.

Tell your doctor if you have ever had:

  • a weak immune system (caused by disease or by using certain medicines);
  • stomach or intestinal bleeding;
  • liver disease;
  • heart disease;
  • low levels of potassium or magnesium in your blood;
  • long QT syndrome (in you or a family member);
  • lung disease; or
  • lactose intolerance.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using dasatinib and for at least 30 days after your last dose. Tell your doctor if you become pregnant.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while taking dasatinib and for at least 2 weeks after your last dose.

How should I take dasatinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take dasatinib with or without food. Take the medicine at the same time each day.

Swallow the tablet whole and do not crush, chew, or break it.

Do not take a pill that has been accidentally broken. The medicine from a crushed or broken pill can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Wear rubber gloves while handling a broken tablet or capsule. Ask your doctor or pharmacist how to safely dispose of the broken pill. A pregnant woman should not handle a broken pill.

Dasatinib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

Do not change your dose or stop using dasatinib without your doctor's advice.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking dasatinib?

Grapefruit may interact with dasatinib and cause side effects. Avoid consuming grapefruit products.

Avoid taking an antacid within 2 hours before or after you take dasatinib. Some antacids can make it harder for your body to absorb dasatinib.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of dasatinib?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor right away if you have any symptoms of pulmonary arterial hypertension (PAH), such as:

  • chest pain, feeling tired or short of breath (even with mild exertion);
  • swelling in your feet, lower legs, or midsection;
  • blue-colored lips and skin; and
  • a light-headed feeling, like you might pass out.

Also call your doctor at once if you have:

  • severe ongoing nausea, vomiting, or diarrhea;
  • severe headaches, extreme tiredness, muscle or joint pain;
  • pain when you breathe, shortness of breath (especially when lying down);
  • swelling, rapid weight gain;
  • chest pain, shortness of breath, pounding heartbeats or fluttering in your chest, vision problems or slurred speech;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), pinpoint purple or red spots under your skin;
  • liver problems --loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • other signs of bleeding --blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, confusion, headache, problems with speech;
  • low blood cell counts --fever, chills, tiredness, flu-like symptoms, mouth sores, skin sores, pale skin, cold hands and feet, feeling light-headed; or
  • signs of tumor cell breakdown --tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.

Dasatinib may affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • nausea, diarrhea, stomach pain;
  • headache, muscle pain, pain in your hands or feet;
  • breathing problems;
  • skin rash; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dasatinib?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Dasatinib may increase your risk of severe or fatal bleeding, especially if you also use a blood thinner or any medication to prevent blood clots.

Many drugs can affect dasatinib, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about dasatinib.

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