brigatinib

What is the most important information I should know about brigatinib?

What is brigatinib?

Brigatinib is used to treat non-small cell lung cancer that has spread to other parts of the body (metastatic) after other treatments have failed.

Brigatinib is used only if your cancer has a specific genetic marker (an abnormal "ALK" gene). Your doctor will test you for this gene.

Brigatinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking brigatinib?

Tell your doctor if you have ever had:

• lung disease or breathing problems;
• slow heartbeats;
• high blood pressure;
• vision problems;
• diabetes or glucose intolerance;
• pancreas problems;
• liver disease; or
• kidney disease (or if you are on dialysis).

You may need to have a negative pregnancy test before starting this treatment.

• If you are a woman, do not use this medicine if you are pregnant. Brigatinib can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use an effective non-hormonal form of birth control such as an intrauterine device (IUD). Avoid getting pregnant for at least 4 months after your last dose.
• If you are a man, use condoms or other barrier birth control if your sex partner is able to get pregnant. Keep using condoms for at least 3 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using brigatinib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because brigatinib can harm an unborn baby.

How should I take brigatinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Brigatinib is usually taken once per day, with or without food.

If you vomit shortly after taking brigatinib, do not take another dose. Stay on your regular schedule.

Your blood pressure will need to be checked often.

You should not stop using brigatinib unless your doctor tells you to.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

What should I avoid while taking brigatinib?

Grapefruit may interact with brigatinib and lead to unwanted side effects. Avoid the use of grapefruit products.

This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

What are the possible side effects of brigatinib?

• lung problems --cough, trouble breathing, chest pain, fever;
• vision problems --blurred vision, double vision, increased sensitivity to light, seeing flashes of light or "floaters" in your vision;
• high blood pressure --severe headache, pounding in your neck or ears, dizziness;
• high blood sugar --increased thirst, increased urination, hunger, nausea, fruity breath odor, weakness, confusion;
• heart problems --very slow heartbeats, feeling like you might pass out;
• muscle problems --unexplained muscle pain or weakness; or
• pancreatitis --upper stomach pain (worse with eating and may spread to your back), nausea, weight loss.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• nausea, vomiting, diarrhea;
• increased blood pressure;
• trouble breathing;
• cough;
• rash;
• muscle pain;
• headache; or
• feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect brigatinib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect brigatinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about brigatinib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 6/23/2020.