imipenem, cilastatin, and relebactam

What is the most important information I should know about imipenem, cilastatin, and relebactam?

What is imipenem, cilastatin, and relebactam?

Imipenem, cilastatin, and relebactam is a combination medicine that is used to treat complicated infections of the urinary tract (bladder and kidneys) or infections within the stomach area (abdomen).

Imipenem, cilastatin, and relebactam is also used to treat pneumonia (a lung infection) caused by being in a hospital or using a ventilator.

This medicine is for use in adults who have few or no other treatment options.

Imipenem, cilastatin, and relebactam may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving imipenem, cilastatin, and relebactam?

Tell your doctor if you have ever had:

• a seizure;
• a stroke; or
• an allergic reaction to penicillin or other antibiotic medicines.

Tell your doctor if you are pregnant or breastfeeding.

How is imipenem, cilastatin, and relebactam given?

This medicine is given as an infusion into a vein. A healthcare provider will give you this injection.

You should receive this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Imipenem, cilastatin, and relebactam will not treat a viral infection such as the flu or a common cold.

What happens if I miss a dose?

If you receive imipenem, cilastatin, and relebactam in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

What should I avoid while using imipenem, cilastatin, and relebactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What are the possible side effects of imipenem, cilastatin, and relebactam?

• tremors;
• a seizure; or
• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common side effects may include:

• increased blood pressure;
• nausea, diarrhea, vomiting;
• abnormal liver function tests;
• fever;
• headache; or
• pain, bruising, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect imipenem, cilastatin, and relebactam?

Tell your doctor about all your other medicines, especially:

• divalproex sodium;
• ganciclovir; or
• valproic acid.

This list is not complete. Other drugs may affect imipenem, cilastatin, and relebactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about imipenem, cilastatin, and relebactam.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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