lumateperone

What is the most important information I should know about lumateperone?

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

What is lumateperone?

Lumateperone is used in adults to treat schizophrenia.

Lumateperone is also used alone or with lithium or valproate to treat depression with bipolar disorder (manic depression).

Lumateperone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking lumateperone?

Tell your doctor if you have or have ever had:

• heart problems or a stroke;
• high or low blood pressure;
• seizures;
• trouble swallowing;
• low white blood cell count;
• high cholesterol or triglycerides;
• diabetes or high blood sugar, or a family history of diabetes or high blood sugar; or
• liver or kidney disease.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.

This medicine may affect fertility (your ability to have children), whether you are a man or a woman.

How should I take lumateperone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your treatment may also include weight control, and frequent medical tests.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking lumateperone?

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What are the possible side effects of lumateperone?

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

High doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use lumateperone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

• feeling unsteady, feeling like you might pass out;
• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
• tightness in your neck or throat, trouble swallowing;
• trouble breathing or speaking;
• a seizure;
• high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor;
• low white blood cell counts --fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or
• severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

• nausea;
• dizziness;
• drowsiness; or
• dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lumateperone?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect lumateperone, especially:

• an antibiotic, antifungal, or antiviral medicine;
• blood pressure medication;
• bronchodilator asthma medication;
• cold or allergy medicine (Benadryl and others);
• medicine to treat depression, anxiety, mood disorders, or mental illness;
• medicine to treat overactive bladder;
• medicine to treat Parkinson's disease;
• medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;
• seizure medicine; or
• St. John's wort.

This list is not complete and many other drugs may affect lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about lumateperone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01. Revision date: 7/14/2023.