voxelotor
What is the most important information I should know about voxelotor?
Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.
What is voxelotor?
Voxelotor is used to treat sickle cell disease in adults and children at least 4 years old.
Voxelotor is sometimes given together with another medicine called hydroxyurea.
Voxelotor may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking voxelotor?
You should not use voxelotor if you are allergic to it.
Tell your doctor if you have ever had:
- liver problems.
It is not known if voxelotor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.
How should I take voxelotor?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take voxelotor once per day with or without food.
Tablets: swallow the tablet whole and do not crush, chew, or break it.
Tablets for oral suspension: mix the tablets for oral suspension in room temperature clear liquid, such as water, clear soda, apple juice, clear electrolyte drink, clear flavored drink, or clear sports drink, just before taking it. Do not swallow whole, break, crush, or chew the tablets for oral suspension.
Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.
Voxelotor can affect the results of certain blood tests. Tell any doctor who treats you that you are using voxelotor.
You should not stop using voxelotor without your doctor's advice.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
What happens if I miss a dose?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking voxelotor?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What are the possible side effects of voxelotor?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Common side effects may include:
- headache;
- fever;
- hives, rash; or
- stomach pain, nausea, diarrhea, vomiting.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect voxelotor?
Tell your doctor about all your current medicines. Many drugs can affect voxelotor, especially:
- phenobarbital or other barbiturate medicine;
- St. John's wort;
- an antibiotic --rifabutin, rifampin, rifapentine;
- cancer medicine --apalutamide, enzalutamide, mitotane;
- HIV or AIDS medicine --efavirenz, nevirapine;
- seizure medicine --carbamazepine, oxcarbazepine, phenytoin, primidone; or
- steroid medicine --dexamethasone, prednisone.
This list is not complete and many other drugs may affect voxelotor. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Where can I get more information?
Your doctor or pharmacist can provide more information about voxelotor.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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