Pronunciation: VUE tri SIR an

Brand: Amvuttra

What is the most important information I should know about vutrisiran?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What is vutrisiran?

Vutrisiran is used to treat adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis (damage of multiple nerves throughout the body).

Vutrisiran may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using vutrisiran?

Before using vutrisiran tell your doctor about all your medical conditions or allergies.

Vutrisiran may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

How is vutrisiran given?

Vutrisiran is injected under the skin by a healthcare provider once every 3 months.

Your doctor may have you take extra vitamin A while you are using vutrisiran. Take only the amount of vitamin A your doctor has prescribed, especially if you are pregnant.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your vutrisiran injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while using vutrisiran?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of vutrisiran?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • vision problems (especially at night); or
  • dryness of the membrane that lines the eyelids and covers the white part of the eye and cornea (the clear layer in front of the iris and pupil).

Common side effects may include:

  • pain in your hands or feet;
  • joint pain;
  • trouble breathing; or
  • abnormal blood test.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect vutrisiran?

Other drugs may affect vutrisiran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about vutrisiran.

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